Michael Snyder, PhD, is the Stanford Ascherman Professor and Chair of Genetics and the director of the Center for Genomics and Personalized Medicine. He received his PhD training at the California Institute of Technology and carried out postdoctoral training at Stanford University. Dr. Snyder has pioneered the use of “big data” and multiomics to advance scientific discovery and transform health care. His laboratory has invented many technologies that are widely used in medicine and research, including methods for characterizing genomes and their products (e.g., RNA-Seq, NGS paired-end sequencing, ChIP-Chip and later ChIP-Seq, protein arrays, machine learning for disease gene discovery, and wearables for monitoring personal health and exposures). His application of omics and wearables technologies to perform longitudinal profiling of people when they are healthy and ill is transforming medicine and health care. Indeed, his laboratory’s recent work to use smartwatches and wearables to detect illness prior to symptom onset, including infectious diseases such as COVID-19, is being used by many thousands of people. He has helped colead many large-scale projects, including ENCODE, HMP, HuBMAP, and HTAN. He has cofounded 16 biotechnologies companies, including Personalis, Q Bio, January AI, Filtricine, RTHM, Marble Therapeutics, and iollo.